4:03 p.m. on May 14, 2008 (EDT)
Most water filters will not remove viruses or chemical contamination (agricultural runoff of pesticides and fertilizers, for example, or industrial wastes, such as the mercury salts found here in the SFBay area in Almaden Valley and the parks in that area).
But in most areas these are very low risk. Certainly in areas such as along the Appalachian Trail, in the White Mountains of NH, Adirondacks, Rockies, Sierra, European Alps, etc, the risk is very low. The places where the risk of viruses is significant are those in which sanitation is poor (many 3rd world countries). Chemical contamination is generally pretty well known, though even along the Ohio, Mississippi, and Missouri systems, the volume of water is great enough that the contamination is low enough to not be a problem for the occasional user out for a few weekends a year. Actually, the risk for the resident of, say, Baton Rouge, who drinks treated water from the city water supply is higher (the statistics on cancer for Baton Rouge residents are higher than, say, St Louis for those cancers that appear to be related to the carcinogens found in the city water supplies).
That said, there are water filters that have carbon elements that at least partially remove the chemical contaminants, and there are methods of killing the viruses (iodine and chlorine compounds and resins in certain filters).
Your main risk from the water is actually bacteria and larger organisms like giardia. The Miniworks and other backpacking filters do just fine with those.
There are some other approaches as well, which I spent time looking into before my December trip to Africa. I am supposed to write an overview and my own experiences up for Trailspace, if I can just get a few more things out of the way. But just briefly -
Filters - all do just fine on bacteria and protozoa. Some do ok on viruses of concern. Some will reduce chemical contamination (not eliminate, though)
Boiling - heating the water to 155F or greater will kill most organisms, including viruses. Some protozoan cysts will survive, but are killed if the water is held above 155F for a few minutes. Actual boiling is not necessary until you get to extreme altitudes (like on Everest).
Chemical - iodine and chlorine dioxide (and sodium hypochlorite = bleach) will kill bacteria, protozoa, and viruses, given sufficient time. But it is 30 min for iodine (and some people are sensitive to iodine), 4 hours for chlorine dioxide, and highly dependent on temperature (cold water takes much longer to act fully).
chelating approaches - Pur (a division of Procter and Gamble) makes a kit for 3rd world countries with poor sanitation that will collect the organisms in a flocculus (kind of a cottony looking mass) that settles, allowing decanting, as well as chelating a number of metal compounds and chemical contaminants. I have been doing a little testing of this.
Ultraviolet - Steripen is one example. The ultraviolet radiation kills most organisms. It does require fairly clear water (not as super clear as I had originally thought). It does not remove chemical contaminants.
In short, unless you are going to be on the rivers where there is lots of industrial and agricultural runoff for more than the occasional weekend, your Miniworks will be just fine. Actually your biggest risk is you and your companions not thoroughly washing and sterilizing your hands, water containers, and cook gear before food is handled. The studies in backcountry travel have shown that the vast majority (something like 80% or more) of backcountry illness is from improper food handling, not from the water. As your mother always told you - wash your hands before eating and after going to the bathroom.